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Breast Cancer Res ; However, the remainder had a more minor calculated impact [ 73 ]. Concise handbook of familial cancer susceptibility syndromes—second edition.

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JAMA ; There are subpopulations with higher frequencies due to founder mutations, most prominently the Ashkenazi Jewish population, in which three major mutations BRCA1. J Natl Cancer Inst ; This substantially reduces the risk of ovarian cancer though there is a residual risk of primary peritoneal cancer , and significantly reduces breast cancer risk if carried out before menopause [ 31 , 32 ]. Story Source:

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BMC Cancer ; 9: Support Center Support Center. The emerging landscape of breast cancer susceptibility.

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Furthermore, this process may be useful in detecting mutation changes not identified by conventional sequencing, such as large rearrangements [ 86 ]. Basal-like breast cancer: Breast cancer high-penetrance genes and their associated syndromes. Calibration of multiple in silico tools for predicting pathogenicity of mismatch repair gene missense substitutions.